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I have tried all kinds of sleep medicines. I am 6'1" and was at 205 pounds for 7 years. I take 800 mg to 1,400 mg of Seroquel daily. My issue is either I don't sleep at all and lose weight or sleep great and become morbidly obese. Then, I eventually become sleepy and nod off. Seroquel in one year now has put me to 250. When I started talking Bipolar Meds I gained 75 lbs. I NEED steady sleep and without Seroquel I. If I don’t take it at the same time, I get manic. Dosage According to studies, increasing the dosage of Seroquel is unlikely to facilitate additional weight gain One can counter this weight gain by eating a healthy diet of fruits, vegetables, whole grains (if you are not gluten intolerant), low fat dairy products & lean meat. This change in lifestyle is the healthiest way to combat Seroquel and weight gain. Another thing I do is fill up on water and coffee If the weight gain is a big deal, a doctor may be able to substitute other medications that may be less likely to increase your weight. I was switched from 200mg of seroquel that I've been taking for almost 6 months to abilify today. 4k views Reviewed >2 years ago Thank. To manage Seroquel and weight gain, the user should maintain regular exercise, preferably more than their normal routine, as antipsychotics slow the body’s metabolism. Avoid sodas, processed foods & excess carbohydrates as much as possible. Topiramate has been shown, in some studies, to reduce appetite and limit. Moderate exercise 30 min/day at least 5 days a wk also helps. Also, patients should find cheap and healthy alternatives for fast food. ) Add topiramate ( Topamax) to the mix. I have managed to lose some weight by using a food diary. I gained about 30lbs on seroquel, even with such a low dose. Massive weight gain on Seroquel. I feel so bad with all of this weight. Choose low-calorie foods like fresh fruits and vegetables, eat fiber-rich and slow-to-digest complex carbohydrates, and drink lots of. At least in my case I don't fill up on snacks etc. The weight gain was a depressing, and impossible to manage even with a change to a healthier diet and increased activity level (This does not have any scientific support at the moment, but it doesn’t hurt to try. Fast food is the quickest and most affordable way to satisfy calorie cravings Physicians recommend a heart-healthy diet, avoiding food high in fats and cholesterol, and an increase of daily exercise. Control weight with or without the added effects of medication. If you go to this, you must write down everything you eat, every day. What I did, still do now also for I've replaced the seroquel with Remeron, and am gaining weight. I take it early in the evening, and when the hungar pains kick in, eat my evening meal.